Preventive Care for the Elderly

Senior Citizens Benefit from Health Maintenance Programs

Stephen Allen Christensen @ suite101.com

Aging baby boomers want to remain healthy as they look toward retirement and beyond. Guidelines for maintaining optimal health in geriatric populations can help.

Studies show that older individuals benefit from adhering to preventive health care guidelines. Recommendations for health maintenance depend not only on personal expectations, but on population dynamics as well.

Causes of Mortality

Many of the leading causes of death in older adults are mirrored by modifiable risk factors—called “actual causes of death”—that have become part of the American lifestyle:

  • Leading causes of death: Heart disease, cancer, stroke, emphysema, diabetes, Alzheimer’s disease, infection
  • Actual causes of death: Tobacco use, poor diet, physical inactivity, alcohol consumption, microbial agents, toxic agents, motor vehicle crashes, firearms, sexual behaviors, illicit drug use

Changes in lifestyle can potentially mitigate some aspects of mortality. This holds true even for elderly adults: For example, smoking cessation at the age of 65 increases life expectancy by approximately 1.7 years in men and 3.2 years in women.

Preventive Strategies
  • Tobacco cessation: Smoking cessation at any age benefits the smoker. Additionally, people exposed to secondhand smoke experience significant reduction in risk. Current recommendations include frequent counseling sessions between physicians and patients; medications are discretionary.
  • Improved nutrition: Elimination of dietary trans-fats would prevent 6 to 19 percent of all coronary events in the US each year. A healthy diet (e.g., Mediterranean) in association with other desirable health practices has been shown to reduce all-cause mortality by up to 50%. Anyone with diet-related illness (diabetes, hypertension, hypercholesterolemia, obesity) should receive nutrition counseling.
  • Exercise: Regular exercise helps to prevent osteoporosis and obesity, and benefits those with hypertension, diabetes, and cardiovascular disease. The US Surgeon General recommends that all adults participate in aerobic activity three times weekly for at least thirty minutes, in addition to twice-weekly strength training.
  • Aspirin: For those at highest risk for heart disease, daily aspirin therapy should be considered. Those aged 70 to 84 benefit the most, but others who might benefit include men older than 40, postmenopausal women, and premenopausal women who smoke or who have hypertension or hypercholesterolemia. Aspirin, however, can contribute to gastrointestinal or intracranial bleeding.
  • Cholesterol reduction: Statin therapy is currently recommended for elderly patients with elevated cholesterol and other risk factors for cardiovascular disease.
  • Immunizations: Annual influenza vaccination is recommended for those 55 years and older, as is a one-time pneumococcal vaccine at age 65. Tetanus and diphtheria immunity should be updated and renewed every 10 years thereafter.
Screening
  • Breast cancer: Mammography is recommended every one to two years for women aged 40 years and older who have a life expectancy of five or more years.
  • Cervical cancer: This disease is rare in women over 65 who have had previous normal (negative) screens. Pap smears for previously-screened women over 65—and for those who have had a hysterectomy for benign reasons—are not recommended.
  • Colorectal cancer: This cancer doubles in incidence every seven years beginning at age 50. Men and women 50 years and older with a life expectancy of five years or more should be screened with either colonoscopy (repeated every 10 years), flexible sigmoidoscopy every five years, or yearly fecal occult blood testing.
  • Prostate cancer: Because of the unclear benefit of treatment, screening with PSA or digital rectal examination is not recommended for men with a life expectancy of less than 10 years.
  • Osteoporosis: Screening for women should begin at age 65; those with risk factors (daily steroid use, family history, menopause before age 45, or infrequent menses) should be screened earlier.
  • Abdominal aortic aneurysm: In men between the ages of 65 and 75, repair of large aneurysms in the abdominal aorta significantly reduces mortality. A one-time ultrasound is recommended for men in this age group who have never smoked. Smokers carry a higher risk, and should be screened earlier and/or more frequently.

Clearly, each individual’s health risks vary, and one’s life expectancy is influenced by many factors. Patients and their physicians should discuss preventive health issues at every opportunity.

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Prevailing Theory of Aging Challenged in Stanford Study

STANFORD, Calif. — Age may not be rust after all. Specific genetic instructions drive aging in worms, report researchers at the Stanford University School of Medicine. Their discovery contradicts the prevailing theory that aging is a buildup of tissue damage akin to rust, and implies science might eventually halt or even reverse the ravages of age.

“We were really surprised,” said Stuart Kim, PhD, professor of developmental biology and of genetics, who is the senior author of the research.

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Healthy Aging: Lessons from the BLSA

National Institute On Aging Publication (Excerpts)

Over the years, BLSA scientists and other researchers from a broad range of disciplines have identified factors that influence healthy aging. From their research have come action steps we can take to maintain our health and function as we get older. From diet and physical activity to health screening and managing disease risk factors, these actions may influence different areas of our health.

The following review of selected findings from the BLSA and other studies describes in practical terms some of the evidence for actions that may lead to healthy aging. Not all the information will necessarily relate to your needs or fit with your lifestyle. But these findings will provide a context and general ideas for you to consider — and act on — as you think about your own aging. Before trying anything new, talk with your doctor about some of the approaches presented here to determine which might best apply to you.

Get Moving: Consider Exercise and Other Physical Activities
Some people love it, some people hate it, but regardless of your personal feelings, exercise and physical activity are good for you — period. In fact, exercise and physical activity are considered a cornerstone to almost every healthy aging program. Emerging scientific evidence suggests that people who exercise regularly not only live longer, they live better. And, being physically active — doing everyday activities that keep your body moving such as gardening, walking the dog, and taking the stairs instead of the elevator — can help you to continue to do the things you enjoy and stay independent as you age.

Specifically, regular exercise and physical activity can reduce your risk of developing some diseases and disabilities that often occur with age. For instance, balance exercises help prevent falls, a major cause of disability in older adults. Strength exercises build muscles and reduce the risk of osteoporosis. Flexibility or stretching exercises help keep your body limber and give you the freedom of movement you need to do your everyday activities.

Exercise may even be an effective treatment for certain chronic conditions. People with arthritis, high blood pressure, or diabetes can benefit from regular exercise. Heart disease, a problem for many older adults, may also be alleviated by exercise. Scientists have long known that regular exercise causes certain changes in the hearts of younger people. These changes, which include lowering resting heart rate and increasing heart mass and stroke volume (the amount of blood pumped with each heart beat), make the heart a better pump. Evidence now suggests that people who begin exercise training in later life, for instance in their sixties and seventies, can also experience improved heart function. In one study, BLSA researchers observed a decrease in the risk of a coronary event, like a heart attack, in older male BLSA participants who took part in high intensity, leisure time physical activity like lap swimming or running.

In addition to benefits for the heart, studies also show that exercise helps breathlessness and fatigue in older people. Endurance exercises — activities that increase your breathing and heart rate — such as dancing, walking, swimming, or bicycling, increase your stamina and improve the health of your lungs and circulatory system as well as your heart.

There are many ways to be active. You can be active in short spurts throughout the day or you can set aside specific times of the day or specific days of the week to exercise. Many physical activities, such as brisk walking or raking leaves, are free or low-cost and do not require special equipment.

For more information about how to get started and stick with an exercise and physical activity program, get a free copy of Exercise and Physical Activity: Your Everyday Guide from the National Institute on Aging. If you have a chronic health condition, you may want to talk to your doctor about your interest in physical activity and exercise. He or she may have some safety tips to accommodate any health problems you might have.

Pay Attention to Weight and Shape
Weight is a very complex issue. For older people, the health problems associated with obesity may take a back seat to problems associated with body composition (fat to muscle ratio) and location of fat (hip or waist) on the body.

Most of us know that many health problems are connected to being overweight or obese. People who are overweight (defined by a BMI of 25 to 29.9) or obese (a BMI greater than or equal to 30) are at greater risk for type 2 diabetes, high blood pressure, heart disease, stroke, some types of cancer, sleep apnea (when breathing stops for short periods during sleep), and osteoarthritis (the wearing away of joints). But data show that for older adults, thinner is not always healthier, either. In one study, researchers found older adults who are thin (a BMI less than 19) have a higher mortality rate compared to those who are obese or of normal weight. In another study, women with a low BMI had an increased risk of mortality. Being, or becoming, thin as an older adult can be a symptom of disease or an indication of developing frailty. Those are possible reasons why some scientists think maintaining a higher BMI may not necessarily be bad as we age.

For some older adults, problems associated with body composition can be more dangerous than obesity alone. For instance, one study  compared older adults with sarcopenic obesity — a deficiency in skeletal muscle mass and strength as well as a high percentage of body fat — with obese older adults without sarcopenia and with lean older adults with skeletal muscle deficiencies. Scientists found older adults with sarcopenic obesity to have an increased risk of disability for doing instrumental activities of daily living (IADLs). Sarcopenic obesity interfered with the ability to perform such tasks as using the telephone, accessing transportation, getting groceries, making meals, doing housework, and managing money.

Body fat distribution, specifically waist circumference and waist-to-hip ratio, can also be a serious problem for older adults. We know that the “pear” shape, with body fat in peripheral areas such as the hips and thighs, is generally healthier than the “apple” shape, with fat around the waist. Being apple shaped can increase risk of heart disease and possibly breast cancer. According to BLSA research, with age, the pattern for body fat can shift from safer peripheral areas to the abdominal area of the body. BLSA researchers examined 547 men and women over a 5-year period to observe body measurement changes. They found that men predominantly shifted in waist size while women showed nearly equal changes in waist and hip measurements. The men developed a more dangerous body fat distribution, even though women carried more total body fat. This may help explain why men generally have a higher incidence of certain diseases and a shorter lifespan.

So is there a “normal” weight range or pattern for healthy aging? For older adults, one size does not fit all.

On one hand, when deciding whether or not to lose weight, there are a variety of risk factors to consider: high blood pressure (hypertension); high LDL cholesterol (“bad” cholesterol); low HDL cholesterol (“good” cholesterol); high triglycerides; high blood glucose (sugar); family history of premature heart disease; physical inactivity; and cigarette smoking. The National Heart, Lung, and Blood Institute guidelines recommend weight loss for people who are considered obese or overweight and have two or more of these risk factors. Even a small weight loss (just 10 percent of your current weight, for example 16 pounds if you weigh 160 pounds) can help to lower the risk of developing diseases associated with obesity.

On the other hand, it is normal for people to gain some weight with age. While extra weight — especially around the waist or accompanied by loss of skeletal muscle mass — can cause health risks, losing weight may not be a good idea for some older adults. For example, it may be more important for people who are pear shaped and have less than two of the risk factors described above to prevent weight gain rather than try to lose weight. One group of researchers found that involuntary and even voluntary weight loss, regardless of BMI, can actually increase an older adult’s risk of mortality. In another study, scientists had similar findings, reporting that weight change (loss or gain) is associated with mortality risk.

While we have learned a lot about patterns of weight and aging, watching your weight as you age is very much an individual matter. Talk to your doctor about any weight concerns, including decisions to lose weight or if you notice unexplained weight changes.

In Their Own Words: Reflections from the BLSA Staff

Jeanette Wright
I have been working with the Baltimore Longitudinal Study of Aging in the cardiovascular labs since August 23, 1982. From the time I started with the study to the present, I have seen the BLSA change the way society reacts and responds to research. The BLSA has truly spread into a large realm of health care areas concerning the aging process, helping to amend views of aging. The research is important to everyone, but especially to the growing numbers of participants ranging from 60 years and older.

Our BLSA participants are viewed and treated as family members, not study groups. In turn, they often leave one visit looking forward to the next. Many have stated that they would never get this type of testing and concern from their primary care providers. To me, this speaks volumes about the staff of the BLSA.

Over the past 26 years, I personally have valued the relationships I’ve developed with participants. It is the BLSA participants who keep us looking ahead and growing each and every day. Their unselfish participation and willingness to stay with the study year after year allow us to continue our research and hopefully make a difference in the community of health care. Thank you to the participants.

Healthy Food for Thought: Think About What You Eat
You may have heard of the French saying “tell me what you eat and I will tell you what you are” or the shortened American version “you are what you eat.” The insight in both of these sayings speaks to an interplay between food and health. What you eat can either support healthy aging or cause health problems. NIA scientists along with other investigators have found certain components of food, like saturated fats, cholesterol, and trans fats, may increase the risk of age-related disease, whereas foods like vegetables, fruits, fish, and nuts may have health benefits.

This booklet has already discussed how weight and body composition may play a role in how people age. Food has been shown to be an important part of that equation. In one BLSA study, scientists investigated how dietary patterns influenced changes in BMI and waist circumference, risk factors, again, for many diseases. Scientists grouped participants into clusters based on what foods contributed to the greatest proportion of the calories they consumed. BLSA participants who had a pattern of eating “meat and potatoes” had a greater annual increase in BMI, and participants in the “white-bread” pattern had a greater increase in waist circumference compared to those in the “healthy” cluster. “Healthy” eaters had the highest intake of foods like high-fiber cereal, reduced-fat dairy, fruit, nonwhite bread, whole grains, beans and legumes, and vegetables, and low intake of red and processed meat, fast food, and soda. This same group had the smallest gains in BMI and waist circumference.

Scientists think there are likely many factors that contribute to the relationship between diet and changes in BMI and waist circumference. One factor may involve the glycemic index value (sometimes called glycemic load) of food. Foods with a low glycemic index value (such as most vegetables and fruits and high-fiber, grainy breads) decrease hunger but have little effect on blood sugar and therefore are healthier. Foods like white bread have a high glycemic index value and tend to cause the highest rise in blood sugar.

Scientists have also used BLSA data to look at how the diet of male participants influenced risk of mortality from coronary heart disease (CHD) — the leading cause of death for people age 65 and over. Researchers studied the protective effects of eating fruits and vegetables along with the harmful effects of eating saturated fat. As expected, they observed that people who ate fruits and vegetables, particularly vegetables, had proportionately (based on amount of fruits and vegetables consumed) less coronary heart disease mortality. Participants with diets high in saturated fat had proportionately greater risk of CHD death and, conversely, participants on a low saturated fat diet had a lower risk of CHD death. A diet rich in fruits and vegetables and low in saturated fat was even more effective in decreasing risk. These BLSA findings are supported by data from many similar studies.

In addition to the BLSA, other NIA-supported researchers have studied the connection between food and health. For example, the relationship between physical problems and micronutrient or vitamin deficiency is one area of focus. Low concentrations of micronutrients or vitamins in the blood are often due to poor nutrition. A low carotenoid concentration, which can result from not eating enough fruits and vegetables, is associated with a heightened risk for a decline in skeletal muscle among older adults. Low concentration of vitamin E in older adults, especially women, is correlated with a decline in physical function. When compared to other older adults, those with low vitamin D levels had poorer results on two physical performance tests. Women with a low vitamin D concentration were more likely to experience back pain. These studies provide support for the takeaway message: the nutrients you get from eating well can help keep muscles, bones, organs, and other parts of the body strong throughout life.

So, eating well is not just about your weight, it can also help protect you from certain health problems that occur more frequently among older adults. And, eating unhealthy foods can increase your risk for some diseases. If you are concerned about what you eat, talk with your doctor about ways you can make better food choices. You may also want to visit www.MyPyramid.gov, a website developed by the U.S. Department of Agriculture (USDA), offering personalized eating plans, tools to help you plan and assess your food choices, and other advice to help you make healthy food choices.

In Their Own Words: Reflections from the BLSA Staff

Denise Melvin
I have been with the BLSA since April of 2001. I am a Clinical Research Nurse and work closely with the endocrine group. We have been studying the hormone response to the “tasty” orange-flavored drink used for the Oral Glucose Tolerance Test and how hormones are related to diabetes.

I believe that what we know about aging from the BLSA will help lead to future discoveries that will help all generations live healthier and improve and maintain their quality of life. The testing we do is precise and uses state-of-the-art equipment geared toward studying the aging process. Furthermore, the physicians involved in reviewing data and examining the participants are of the highest caliber, extremely knowledgeable, and very respected in their fields.

People are always talking about age 50 as the new 40, and 70 as the new 60. I see that every day here with the BLSA participants. They share with us their new and exciting endeavors, including classes they are taking, world travel, and other life experiences. It is amazing to see how some of our oldest participants have adapted to technology by using computers and e-mail. I am inspired by 80- and 90-year-olds who are routinely doing more exercise than me. I especially admire women of that age group who attended college, raised families, and have contributed so much to our society.

It is a pleasure working with the BLSA participants. You encourage me in so many ways. Happy 50th, and thank you for the contribution of your time and patience!

Participate in Activities You Enjoy
Sure, engaging in your favorite activities can be fun or relaxing, but did you know that doing what you like to do may actually be good for your health? It’s true. According to BLSA data, people who are sociable, generous, and goal-oriented report higher levels of happiness and lower levels of depression than other people. Research from other studies supports this observation.

Participate in your health care

Another component of participation is taking an active role in your health care. This means continually learning about how you can stay healthy. Websites like www.nia.nih.gov, www.nih.gov, medlineplus.gov, and nihseniorhealth.gov provide up-to-date, trustworthy health information. NIHSeniorHealth.gov is an example of a senior-friendly website with special features that make it easy to use. You can have the text read out loud or make the type larger.

People who are involved in hobbies and social and leisure activities may be at lower risk for some health problems. For example, one study followed participants for up to 21 years and linked leisure activities, like reading, playing board games, playing musical instruments, and dancing, with a lower risk for dementia. In another study, older adults who participated in social activities (i.e., played games, belonged to social groups, attended local events, travelled) or productive activities (i.e., had paid or unpaid jobs, cooked, gardened) lived longer than people who did not report taking part in these types of activities.

Other studies have found that older adults who participate in what they see as meaningful activities, like volunteering in their community, reported feeling healthier and happier. Programs like the Experience Corps® are testing this idea, with promising preliminary outcomes. The Experience Corps® is a community-based program that places older adult volunteers living in an urban setting in public elementary schools for approximately 15 hours a week. Results suggest that the first group of Experience Corps® volunteers (living in Baltimore, Maryland) had an increase in physical, social, and cognitive activity levels, which might decrease their risk for disability, dependency, and dementia in later life. In addition to physical health benefits, volunteers reported feeling personal satisfaction from their experience.

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TRANSHUMANISM: The Life Extension Science-Fiction?

TRANSHUMANISM: The Life Extension Science-Fiction?

Over the past few years, a new paradigm for thinking about humankind’s future has begun to take shape among some leading computer scientists, neuroscientists, nanotechnologists and researchers at the forefront of technological development. The new paradigm rejects a crucial assumption that is implicit in both traditional futurology and practically all of today’s political thinking. This is the assumption that the “human condition” is at root a constant. Present-day processes can be fine-tuned; wealth can be increased and redistributed; tools can be developed and refined; culture can change, sometimes drastically; but human nature itself is not up for grabs.

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ProSavin®, a gene-based treatment for Parkinson’s disease, Performs Well in Parkinson’s Trial

Parkinson’s disease currently affects 4.1 million patients globally which is projected to rise to 8.7 million by 2030.  A patient with Parkinson’s disease progressively loses the ability to make the neurotransmitter dopamine, the mediator of the control of movement.  There is no cure for Parkinson’s disease, and no treatment can prevent the disease from progressing, however current treatments can usually ease symptoms.  The current treatment market for Parkinson’s disease is approximately US$3.5 billion.  ProSavin® has the potential to address an unmet medical need in Parkinson’s disease, offering long-lasting benefit from a single administration with an excellent safety profile.

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An Overview: Antioxidant and Anti-Aging Supplements and Vitamins

The term “Antioxidant” refers to a group of organic substances, including vitamins C and E, vitamin A, selenium (a mineral), and a group know as carotenoids – beta-carotene being the most popular and well know carotenoid. Carotenoids are the pigment compounds that give many fruits and vegetables their vibrant colors. Antioxidants are believed to be effective in helping to prevent cancer, heart disease, stroke and a variety of other ailments associated with natural aging. Specifically antioxidants prevent ailments by destroying free harmful radicals inside the human body.

Left unmanaged, free radicals can damage cell walls, genetic material within cells and other cell structures. Over time such damage may lead to disease. Again, antioxidants are believed to assist in preventing disease by destroying free radicals before they get the chance to do harm to your body.

A few studies have shown that smokers with diets high in carotenoids have a lower risk of developing lung cancer relative to smokers whose diets are low in carotenoids. However, another study indicated that some beta-carotene takers, primarily smokers, actually had a higher death rate. Additional research has suggested that diets high in carotenoids may help lower the risk of breast cancer. Vitamin C has been shown to prevent the formation of N-nitroso compounds (cancer-causing substances from nitrates found in some foods).

Many healthcare specialists claim that the elderly, especially those with a reduced food intake, heavy drinkers, frequent aspirin users, smokers and individuals with immune problems may benefit greatly by taking daily antioxidant supplements. It is also possible that higher level of antioxidants may aid in preventing certain life threatening diseases.

The human body produces a number antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase, and catalase, that destroy many types of harmful free radicals. Supplements of these enzymes are available for oral administration. However, absorption of these enzymes is most likely minimal at best. Supplementing with the components the body requires to make these enzymes may be more effective. These include the minerals managanese, zinc and copper for SOD and selenium for glutathione peroxidase.

In addition to SOD, glutathione peroxidase and catalase, many vitamins and minerals are effective antioxidants in their own right, such as vitamin E, vitamin C, lutein, lycopene, vitamin B2, coenzyme Q10, and cysteine (an amino acid). Herbs, such as grape seed, bilberry, turmeric (curcumin), ginkgo, milk thistle and green tea also contain powerful antioxidant compounds.

Many experts believe that the best way to provide the body with the most complete protection against free radicals is to consume a large variety of antioxidants.

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Aging and Cancer: Issues of Basic and Clinical Science

Oxford Journals > Medicine > JNCI J Natl Cancer Inst > Volume89, Issue20 > Pp. 1489-1497

Aging and Cancer: Issues of Basic and Clinical Science

Abstract

The majority of patients with cancer in the United States are more than 70 years old. Despite the increased understanding of the molecular bases for both oncogenesis and aging, the overlap of cancer and aging at that level remains a wide-open research domain. Similarly, at the clinical level, there is also an increased awareness of the need for more information about the influence of host age on the development of tumors, on the growth and spread of the disease, and on treatment expectations. In this review, we have attempted to frame questions regarding cancer and aging from the perspective of biogerontology and geriatric medicine. An increased effort to address the issues of aging is of paramount importance at all levels of cancer investigation.

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Therapeutic cloning: new paradigm for regenerative and stem cell therapy?

Therapeutic cloning: new paradigm for regenerative and stem cell therapy?

Somatic cell nuclear transfer (SCNT) entails the removal of an oocyte nucleus followed by its replacement with a nucleus derived from a somatic cell obtained from that patient. Activation with chemicals or electric shock stimulates cell division up to the blastocyst stage at which time the inner cell mass is isolated and cultured, resulting in ESC. This approach is distinct from reproductive cloning because the blasotcyst is not transplanted back to the uterus. Hence, development does not proceed beyond the 100 cell stage. This process also differs from fertilization since no sperm is used in this process. The resulting ESC are perfectly matched to the patients immune system and no immunosuppressants would therefore be required to prevent rejection.

While interest in the field of nuclear cloning remains high since the birth of Dolly (1997), the first successful nuclear transfer was actually reported over fifty years ago by Briggs and King. Cloned frogs, which were the first vertebrates derived from nuclear transfer, were subsequently reported by Gurdon in 1962 although the nuclei were derived from non-adult sources. Indeed, in just the past six years alone important advances in nuclear cloning technology have been reported – a pace of discovery that betokens the relative immaturity of this research arena. In fact Dolly was not the first cloned mammal to be produced from adult cells. Live lambs were produced in 1996 using nuclear transfer and differentiated epithelial cells, although these were derived from embryonic discs. To be sure, the significance of the Dolly report was that this described the first mammal to be derived from an adult somatic cell using nuclear transfer. Subsequently, animals from several species have been grown using nuclear transfer technology, including cattle, goats, mice, and pigs.

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ALT-711: Safe and Effective Anti-AGE-ing Therapy

ALT-711: Safe and Effective Anti-AGE-ing Therapy

source: www.vanuatumedical.com

As we age, a non-enzymatic reaction between sugars in the blood and amino groups in our body’s
proteins, fats, and DNA, produces compounds called advanced glycation
end-products (appropriately called AGEs). AGEs bond to one another,
creating crosslinks between proteins that disrupt normal cellular
activity. By stiffening collagen and elastin (the key proteins of the
extracellular matrix in all tissues), AGEs promote high blood pressure,
atherosclerosis, and heart failure. In the kidneys, AGEs target
nephrons, the filtering units that remove wastes from the blood.

Not
only do AGEs wreak havoc on extracellular matrix proteins, they also
activate AGE receptors (called RAGEs) on cells throughout the body.
RAGEs trigger the release of a wide variety of compounds involved in
inflammation and the creation of stiff fibrous tissue, compromising
function in the heart, blood vessels, kidneys and brain.

In
addition to chronological aging, AGE formation is greatly increased by
high blood sugar levels and plays a central role in all diabetes-related
disease complications.

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Genetically modified cells in regenerative medicine and tissue engineering

Genetically modified cells in regenerative medicine and tissue engineering

Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):683-98. Epub 2010 Jan 28.

Regenerative medicine appears to take as its patron, the Titan Prometheus, whose liver was able to regenerate daily, as the field attempts to restore lost, damaged, or aging cells and tissues. The tremendous technological progress achieved during the last decade in gene transfer methods and imaging techniques, as well as recent increases in our knowledge of cell biology, have opened new horizons in the field of regenerative medicine. Genetically engineered cells are a tool for tissue engineering and regenerative medicine, albeit a tool whose development is fraught with difficulties. Gene-and-cell therapy offers solutions to severe problems faced by modern medicine, but several impediments obstruct the path of such treatments as they move from the laboratory toward the clinical setting. In this review we provide an overview of recent advances in the gene-and-cell therapy approach and discuss the main hurdles and bottlenecks of this approach on its path to clinical trials and prospective clinical practice.

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