Stem Cell Biology and Regenerative Medicine: Transforming the Way We Heal

For a moment in time, an embryonic stem cell has infinite possibilities. These “master” cells that form part of a newly created embryo have the capacity to grow into literally any tissue the body might require: bone, hair, nerves, muscle, blood, heart, anything. Once an embryonic stem cell chooses its path, however, there’s no turning back.

But what if we could harness the power of these cells before their course is determined? Researchers believe that stem cells, sometimes referred to as the body’s own “repair kit,” could have tremendous potential to cure diseases and disorders ranging from Parkinson’s and Alzheimer’s to multiple sclerosis, diabetes, heart disease, and even cancer.

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A Younger Look May Mean Living Longer

Have you ever had someone ask your age, and then be shocked at your response? “You look so young! I never would have guessed it!” I used to hear those comments all the time before I had kids, but I think the lack of sleep and stress of children has aged me a little. It’s definitely been worth the tradeoff, but now a new study reveals that looking younger may mean you live longer.

The University of Southern Denmark did a study of twins over the age of 70. They were photographed, and then took various physical and cognitive tests. The study tracked the twins for 7 years, and found that perceived age was associated with survival. The older-looking twin was more likely to die before the younger-looking one. The research also showed a relationship between perceived age and physical and mental capabilities.

According to the study, “Perceived age—which is widely used by clinicians as a general indication of a patient’s health—is a robust biomarker of ageing that predicts survival among those over 70 and correlates with important functional and molecular ageing phenotypes.” So basically, a younger look may mean a longer life.

By: Jen Mueller

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AGING AS A CONSEQUENCE OF MISREPAIR — A NOVEL THEORY OF AGING

Introduction to A NOVEL THEORY OF AGING –

AGING AS A CONSEQUENCE OF MISREPAIR

Jicun Wang1, Thomas M. Michelitsch2*, Arne Wunderlin3 and Ravi Mahadeva1

1Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom

2Institut Jean le Rond d’Alembert CNRS UMR 7190, Université Pierre et Marie Curie (Paris 6), 4 Place Jussieu, 75252 Paris cedex 05, France

31. Institut für Theoretische Physik, Pfaffenwaldring 57/4, D-70550 Stuttgart, Germany

*Send correspondence to: Dr. Thomas M. Michelitsch, Email: michel@lmm.jussieu.fr

2 April 2009

Abstract

It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been proposed in the damage (fault)-accumulation theory by Kirkwood 2006. However, this theory fails to explain some aging phenotypes such as fibrosis and premature aging, since terms such as ‘damage’ and ‘fault’ are not specified. Therefore we introduce here a specification of the underlying mechanism of aging and arrive at a novel theory: aging of the body is a result of the accumulation of Misrepair of tissue. It emphasizes: a) it is Misrepair, not the original damage, that accumulates and leads to aging; and b) aging can occur at different levels, however aging of the body takes place at least on the tissue level, but not necessarily on cellular/molecular level. The novel concept of Misrepair introduced here unifies the understanding of the roles of environmental damage, repair, gene regulation, and multicellular structure in the aging process. The Misrepair-accumulation theory introduced in the present paper gives explanations for the aging phenotypes, premature aging, and the difference of longevity in different species, and is consistent with the point of view of physical theory of complex systems.

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Can Social Relationships Promote Longevity?

by CHritz 7. October 2010

Most of us know that having good friends can help enrich our daily lives, but according to a recent study, close friends may do more than provide companionship—it can actually add years to your life. The study, which appeared in the journal PLoS Medicine, found that social relationships—friends, family, neighbors or colleagues—improve our odds of survival by 50 percent. Having low social interactions even compared to the equivalent of smoking 15 cigarettes a day and being more harmful than not exercising. The researchers analyzed 148 studies that examined the effects of social relationships and death risks among 308,849 people for an average of 7.5 years.

The study also found that people with strong relationships may even live an average of four years longer. The challenge according to the authors of the research was to put this information into good use, who noted that in an era of technology, the quality of relationships is decreasing. At Interim HealthCare we understand how important companionship is and how important it is to have someone there to share your thoughts with.

We provide a HomeLife EnrichmentSM program where we focus on the qualities of living an enriched life with one-on-one companionship that eliminates social isolation through several activities such as conversation, brain fitness, life reviews and arts and crafts to name a few.  Our Care Professionals are people with a kind heart who understand the special needs of seniors. Click here to learn more about our personal care & support services.

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The Concept of Cancer Stem Cell

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample. CSCs are therefore tumorigenic (tumor-forming), perhaps in contrast to other non-tumorigenic cancer cells. CSCs may generate tumors through the stem cell processes of self-renewal and differentiation into multiple cell types. Such cells are proposed to persist in tumors as a distinct population and cause relapse and metastasis  by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially for sufferers of metastatic disease.

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An Introduction to Evolutionary Theories of Aging and Longevity

Leonid A. Gavrilov* and Natalia S. Gavrilova  (Excerpts)

Center on Aging, NORC/University of Chicago, 1155 East 60th Street, Chicago, IL 60637

Abstract

The purpose of this article is to provide students and researchers entering the field of aging studies with an introduction to the evolutionary theories of aging, as well as to orient them in the abundant modern scientific literature on evolutionary gerontology. The following three major evolutionary theories of aging are discussed: 1) the theory of programmed death suggested by August Weismann, 2) the mutation accumulation theory of aging suggested by Peter Medawar, and 3) the antagonistic pleiotropy theory of aging suggested by George Williams. We also discuss a special case of the antagonistic pleiotropy theory, the disposable soma theory developed by Tom Kirkwood and Robin Holliday. The theories are compared with each other as well as with recent experimental findings. At present the most viable evolutionary theories are the mutation accumulation theory and the antagonistic pleiotropy theory; these theories are not mutually exclusive, and they both may become a part of a future unifying theory of aging.

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The Natural Anti-Inflammatory Diet Breakfast

One of the secrets of relieving pain and chronic inflammation is understanding the potential of your kitchen. This is the food your prepare in your home and eat to rebuild your body. Just open your fridge, pause, and look at what your body will be made of tomorrow.

Food for thought? Good – Now we can get started.

In this article we will create a wonderful natural anti-inflammatory and antioxidant breakfast that will give you energy and a great start to your day. Interested? Excellent.

First I would like to introduce you to what I consider to be the greatest culinary invention of the last hundred years. The magical blender. No, not the juicer which separates the vital fiber from everything. Nor the food processor which does no more than a good knife and spoon and takes away the meditation from cooking.

Several mornings each week start with the Hamilton Shake, THE natural anti-inflammatory breakfast.

Nothing comes out of a plastic tub at vast expense from a health store, in fact this is very economical. It goes like this:

The Ingredients for an Anti-Inflammatory Diet

I usually cut a pear, which are my favorite, into chunks and put it in the blender.

Depending on what is in the grocers it could also be an apple, papaya, mango, kiwi, grapefruit, pineapple or something that catches my eye.

Then I add half a cup of my seed mix made from equal parts of sunflower, sesame, flax and pumpkin. This delivers Essential Fatty Acids (Omega 3) and protein with all the goodies of the whole seed with its fiber. I buy a pound of each at a time. Mix them and store this in a big jar in the fridge.

Then I add berries. The dark berries, blueberries, blackberries and so on, are loaded with antioxidants called flavonoids and are just as good as the exotic, highly priced stuff from the Amazon. They freeze really well. My freezer is nearly full by the end of the season and this lasts the year.

This is the base. Then in go the super extras:

Tumeric is one of the very best anti-inflammatory herbs in nature. I can get fresh Turmeric in my local store, I put in a chunk about the size of the top joint of my thumb. This is a huge dose of curcumin with all the extras of the whole food.

I can also get fresh Burdock root, a wonderful liver and blood cleansing herb. A chunk the size of my finger goes in. This is called Gobo in Asia and eaten as a vegetable.

The Stinging nettle season is on where I live and I pick this from the wild.

They don’t sting you when you blend them. The mix inactivates the sting and the natural minerals and anti-inflammatory action does you a power of good and suppresses allergies too. In goes a handful. They are great dried.

You can also cut up raw carrots or celery.

Here is the key: I put in all sorts of other things according to my mood and what’s looking at me out of the cupboard.

The only limit is your imagination and your growing level of knowledge.

Play with it. You will save yourself hundreds of dollars in supplements and drugs.

Add water and blend until smooth, adding cold or warm water (almond milk unsweetened is also fine) as needed to achieve your preferred consistency. If you have more than you need for breakfast save some until later.

This mix, taken for breakfast or at any other time, is an excellent nutrient meal and a well tolerated delivery system for large quantities of nutrients and healing herbs.

Have fun and know that you are reducing inflammation, oxidation and pain.

Rowan Hamilton is a Herbalist and writes about natural anti-inflammatory foods, among other health related topics

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125-Year-Old Woman Tops the Longest Living Chinese list

China issued its latest list of the 10 longest-living people Saturday, topped by a woman from Southwest China believed to be the oldest on the mainland. She just celebrated her 125th birthday.

The list was released in honor of Chongyang Festival, also known as Seniors’ Day.

There are now more than 43,000 people in China who are 100 years or older, according to a recent survey.

This moves the nation into second place in the number of centenarians worldwide, with the United States coming in first and Japan now third.

China’s oldest woman Luo Meizhen of the Yao ethnic group, was born in 1885 at Bama county of the Guangxi Zhuang autonomous region.

She is illiterate and has led a simple life as a housewife.

“I almost forget how long I’ve been living and for me, tolerance is the key to longevity,” she said in a phone interview.

The 10 oldest have an average age of 117. They include six women, and come from the provinces and autonomous regions like Hainan and Xinjiang, from five different ethnic groups, according to the China Gerontological Society.

The society made the list based on surveys and the population census. It’s the second time the society has released such a list.

“The number of centenarians has kept rising in China given the economic development and improved quality of life and healthcare,” said Li Bengong, the society’s director.

Ten centenarian couples were also honored. China has counted 43,708 people aged 100 or older, up 8 percent over 2009, official statistics showed. Most of them live in Southwest China.

Worldwide, the US holds the largest centenarian population, estimated at 96,548 as of 2009, according to the International Association of Gerontology. Japan now ranks third, with 40,449 as of a September tally.

Starting in 2007, the China Gerontological Society has identified nine “longevity cities,” including Yongfu and Dongxing in Guangxi, Pengshan and Dujiangyan of Sichuan, and Sanshui in Guangdong.

In each of these places, there are at least seven centenarians per 100,000 locals, more than twice the national average.

As the average life span of the Chinese has more than doubled from only 35 years in 1949 when the People’s Republic of China was founded, the number of centenarians has increased by more than 10 times over the same period of time, statistics showed.

In China’s 1953 national census, 3,384 centenarians were identified.

Medical science attributes increasing longevity to a combination of body exercise, genetics and improved diet.

“Active centenarians are role models for the future of aging,” said professor Wu Cangping with the Population Development Research Center of Renmin University of China.

He also urged improved care for the aged as China is challenged to cope with a fast-growing population of elderly people.

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A New 30-second Alzheimer’s Screening Test Will Offer Early Detection

A New 30-second Alzheimer’s Screening Test Will Offer Early Detection

SOURCE: Brunel University news release, Nov. 10, 2010

by Deborah Mitchell @ emaxhealth.com

Scientists believe they will soon have a screening test that can detect Alzheimer’s disease in 30 seconds. The simple test, which could be available as quickly as two years, could be done in a doctor’s office.

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