The Systems Biology of Stem Cells

Understanding the workings of stem cells is now seen as essential to the progress of regenerative medicine, tissue engineering and cancer therapeutics. Recently, there has been a growing awareness that the behaviors of stem cells emerge out of the highly complex interactions of dynamic networks of gene regulation and proliferative control. The need to describe, predict, and ultimately understand such interactions is drawing ideas and investigators from the field of systems biology into stem cell biology.

The last few years have seen significant advances in our understanding of the molecular mechanisms of stem-cell-fate specification. New and emerging high-throughput techniques, as well as increasingly accurate loss-of-function perturbation techniques, are allowing us to dissect the interplay among genetic, epigenetic, proteomic, and signaling mechanisms in stem-cell-fate determination with ever-increasing fidelity.

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The Consequences Of An Expanding Waist Line

Lose Fat From Your Midsection And Increase Your Life Expectancy

How many of us as we get older begin to widen across out midsection? Carrying excess weight around our midsection does more than expand your waist line. The consequences of an expanding waist line have several far reaching negative health effects. Apart from making you overweight, the excess fat causes disease such as Heart disease, Lung Cancer, Breast Cancer, High Blood Pressure and Diabetes – just to name a few.

Research has found over the years that the fat around our midsection isn’t just simply lying there to be ‘exercised’ off. These cells are actually quite active and can produce hormones that increase insulin resistance, which can lead to Type 2 Diabetes. Other types of hormones released can cause oestrogen to be released after menopause that possibly may increase the chance of breast caner.

As we age our metabolism slows down, and the fat in our bodies increases. Although we may have the belly bulge we can see on the outside, it’s the fat on the inside that is most cause for concern. This fat is ‘visceral’ fat and lies deep inside your abdomen and encases all your internal abdominal organs. It is important to know the more of this type of fat we have, the more increased risk we have of acquiring the diseases mentioned above.

In America alone research has found that more than half the men are obese or over weight, often carrying the excess weight known as having a beer belly, or pot belly. Women also have the same problem, however usually as they get older (and after menopause) the fat shifts to the hips, thighs and legs.

To much fat around your middle (or anywhere on your body for that matter) is extremely unhealthy and has many unhealthy consequences as outlined above. In order to maintain health we must lose the belly fat through good consistent exercise and improved eating habits, which will in turn improve your metabolism. This activity combined will put you at a reduced risk of health problems while improving existing health problems.

It is never to late to embark on a healthy lifestyle change, to increase your chance of living longer, and eliminating unwanted health risks associated with excess belly fat. A few simple changes to your diet and an increase in physical activity can make a world of difference, and could be the difference between life and death. You will not only lose the excess fat, but you will feel better and have alot more energy. Your life expectancy will also increase allowing you to spend more time with loved ones – so it is well worth the change in lifestyle to keep your health.

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Stem cell platforms for regenerative medicine

Clin Transl Sci. 2009 Jun;2(3):222-7.

The pandemic of chronic degenerative diseases associated with aging demographics mandates development of effective approaches for tissue repair. As diverse stem cells directly contribute to innate healing, the capacity for de novo tissue reconstruction harbors a promising role for regenerative medicine. Indeed, a spectrum of natural stem cell sources ranging from embryonic to adult progenitors has been recently identified with unique characteristics for regeneration. The accessibility and applicability of the regenerative armamentarium has been further expanded with stem cells engineered by nuclear reprogramming. Through strategies of replacement to implant functional tissues, regeneration to transplant progenitor cells or rejuvenation to activate endogenous self-repair mechanisms, the overarching goal of regenerative medicine is to translate stem cell platforms into practice and achieve cures for diseases limited to palliative interventions. Harnessing the full potential of each platform will optimize matching stem cell-based biologics with the disease-specific niche environment of individual patients to maximize the quality of long-term management, while minimizing the needs for adjunctive therapy. Emerging discovery science with feedback from clinical translation is therefore poised to transform medicine offering safe and effective stem cell biotherapeutics to enable personalized solutions for incurable diseases.

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Poor People In Well-to-Do Neighborhoods Face Higher Death Rates

source: www.sciencedaily.com News

By living in a well-to-do neighborhood, poor people increase their risk of death, according to a new study by Stanford University School of Medicine researchers to be published in the December issue of the American Journal of Public Health.

“We tend to assume that people living in a high socioeconomic status neighborhood are well off,” said Marilyn Winkleby, PhD, associate professor of medicine at the Stanford Prevention Research Center and lead author of the study.

Instead researchers found that death rates were highest among people of low socioeconomic status who also lived in affluent neighborhoods. That finding surprised the researchers, but “every way we looked at the data, we found the same result,” said co-author Catherine Cubbin, PhD, a former research associate at Stanford who is now a researcher at UC-San Francisco and University of Texas-Austin. The researchers said the findings also indicate that this particular group of people might be medically underserved and need more targeted services and attention by health policy makers.

Previous studies had shown that neighborhood plays an important role in an individual’s health. Most studies have found that people fare better in high-income neighborhoods. The Stanford study is unique because it combined individual economic status with neighborhood status to gain a more refined look at the issue.

The researchers discovered the trend by analyzing data from another study that looked at the incidence of heart disease risk factors in California between 1979 and 1990. The study followed 8,200 men and women from 82 neighborhoods in Monterey, Modesto, Salinas and San Luis Obispo over 17 years.

The researchers used income and education to determine individual socioeconomic status. They then divided people into low, moderate or high socioeconomic groups. Similarly, the researchers classified neighborhoods as being of low, moderate or high socioeconomic status.

The study found that over time, the differences in death rate between the groups became more pronounced. After 17 years, 19 out of every 1,000 women of low socioeconomic status who lived in wealthier neighborhoods had died, compared with 11 of every 1,000 from poorer neighborhoods. The trend was similar, but less dramatic in men.

They found that age as well as a number of risk factors, such as obesity, hypertension and smoking, did not account for their results. There were also no differences in the causes of death, which were largely due to chronic diseases, the researchers said. They also found that access to neighborhood goods and services, such as health care, grocery stores, parks and gyms, did not explain their findings.

Winkleby suggested two explanations for the discrepancy. The first is purely economic, as the cost of living in an affluent neighborhood could leave poor people with little disposable income to spend on essential goods and services, such as health care and healthy food, and less time to take advantage of the benefits of living in a high-income neighborhood.

“Economically this group may be worse off,” said Winkleby. Access to free social services and health care could also be a factor because these services are often concentrated in low-income neighborhoods, she said.

Another possibility is that poorer people in higher-income neighborhoods fare worse for psychological and social reasons.

A discrepancy in a person’s social position relative to others may have an effect on a person’s health, said Winkleby. “You look out every day and you’re at the bottom of the social ladder,” she added.

The researchers caution that their study does not mean poor people are necessarily better off living in low-income neighborhoods. “There could be other benefits” to living in a wealthier neighborhood, said Cubbin. “We don’t want to imply that poor people should move to poor neighborhoods, where there continues to be great need.”

Moreover, the study highlights the needs of a population that may be overlooked and underserved by government agencies and health workers.

“There’s a group of people really at risk that we’re not even thinking about,” said Cubbin.

Winkleby and Cubbin’s co-author was researcher David Ahn, PhD, also at the Stanford Prevention Research Center. The work was funded by a grant from the National Institutes of Health.

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The Secrets of Anti-Aging Genes

source: Technology Review published by MIT
A new study asks why some people stay healthy into old age.
Jeanne Calment of France, shown here at age 119, died in 1997 at age 122 years and 164 days. Scientists hope a large project to sequence genes in healthy old people will reveal how, like Calment, they live so long.

An ambitious plan to sequence 100 genes in 1,000 healthy old people could shed light on genetic variations that insulate some people from the ailments of aging, including heart disease, cancer, and diabetes, allowing them to live a healthy life into their eighties and beyond. Rather than focusing on genetic variations that increase risk for disease, scientists plan to focus on genes that have previously been linked to health and longevity.

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The Advantages of Curative Regenerative Therapy over Traditional Pharmcotherapy

Regenerative medicine, propelled by the recent progress made in transplant medicine, stem cell biology, and related biomedical fields, is primed to expand the therapeutic armamentarium available in the clinical setting, and thereby, ameliorate disease outcome while reducing the burden of chronic therapy. This progress offers a transformative paradigm with curative objectives and goals to address disease management demands unmet by traditional (pharmaco)therapy. In particular, stem cell-based regenerative medicine is poised to drive the evolution of medical sciences from traditional palliation, which mitigates symptoms, to curative therapy aimed at treating the disease cause.

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Caloric Restriction Prolongs Life

Caloric Restriction Prolongs Life

Extend your life and look younger by following a calorie restriction diet

So what is the real fountain of youth? Many researchers are pointing to caloric-restriction, the lifestyle eating plan of consciously reducing your calories to extend life.

The Longevity Diet is one of a few books that explore the science behind caloric-restriction and offers the ins and outs of how to eat to live a healthier and longer life. Numerous research studies have shown that when mice and other mammals follow a low calorie diet they live longer, healthier and more disease-free lives than those who consume more calories.

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Main focuses and methods for life extension and healthy aging

  1. Genetics: (unfortunately not many of us get to choose our parents!)
  2. Lifestyle: With the reduction of stress, good clean living practices that we all understand such as not smoking, drinking alcohol in moderation, avoiding narcotics, eating fresh foods in a balanced diet, drinking clean pure water and avoiding radiation, heavy metals and pollution etc.
  3. Toxins: Avoiding them as best we can including the lesser known toxins such as fluoride, aluminium and pesticides etc.
  4. Exercise: It doesn’t need to be intense but regular.
  5. Karma: Massage and relaxation techniques to provide inner-calm for the soul.
  6. Nutrition: Undertaken with balanced multi-vitamins and minerals to ensure that all nutritional needs are being met, especially as these needs usually increase with age.
  7. Anti-Oxidants: Using them to eradicate free-radicals (a primary cause of premature aging) and to help eliminate pollutants, in turn this has a major benefit for the long-term health of an individual.
  8. Chelation: To help flush-out heavy metals.
  9. Immune System: Enhancement and support to ensure that infections do not become a major problem and the occasional use (as required) of natural anti-biotics to free yourself from more persistent bacteria and viruses etc. These are very important tasks to ensure that serious aging disorders and diseases do not appear.
  10. Nootropics: The regular use of smart drugs and nutrients to provide the brain remains working at an optimum level and to ensure through enhancement and protection that its too-easy oxidation (deterioration) does not lead to serious senile dementias. This can not be overstated as clearly the brain is the command center of a hierarchy of organs.
  11. Hormone Maintenance: The use of hormones and precursors to ensure that they remain at the approximate levels of healthy 25 year-old and that this in turn leads to improved mental and physical capabilities.
  12. Excess: Keeping age-increasing hormones such as cortisol and prolactin in check and ensuring that age-increasing enzymes such as MAO do not interfere unduly with brain neurotransmitters.
  13. Energy: Provide protection and support for the energy producing processes within the body, especially for the mitochondria (the cells that produce the grandmother hormone pregnenolone and production of the universal energy molecule ATP).
  14. Specifics: Nutritional and medical assistance for individual areas of concern, such as treatment for hair-loss or impotence etc.
  15. Others: Keeping an open mind and utilizing of any other proven sources of benefit, for example the emerging science of electro-magnetic medicine.
  16. Ultimately: Pure anti-aging medicine will lie in the ability to decipher DNA and act upon those results and then in the ability to manipulate DNA for our own needs.
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The Benefits of Therapeutic Massage For Seniors

By Brandon J. Thomas

Complementary medicine, including massage therapy, is becoming increasingly popular among senior citizens. The results of a recent survey conducted by the American Massage Therapy Association showed a threefold increase in the percentage of older adults who received massage therapy within the last year. More than 40 percent of those surveyed said that they use massage therapy to treat health conditions.

Most people experience a rise in aches and pains as they grow older, and range of motion begins to decrease. Depression is also on the rise in older adults, which can be a result of lifestyle changes as well as an increased sense of isolation. Geriatric massage employs particular techniques that aid in pain management, improved stability and muscle tone and an enhanced sense of emotional well-being.

Geriatric massage uses a gentle approach, and can be performed with the client lying down or seated in a wheelchair. Special attention is given to the hands and feet, improving circulation and creating a heightened sense of body awareness. Massage encourages natural joint lubrication, which reduces pain from conditions such as arthritis.

Senior massage is beneficial for a number of conditions, including poor posture, which results from muscle tension.  Massage improves muscle tone and has a positive impact on muscle strength and coordination. This results in improved stability, which in turn helps to reduce the occurrence of injuries due to falls arising from loss of balance.

Disruption in normal sleep patterns, inability to sleep through the night and insomnia are common complaints among the elderly. Massage has been proven to be beneficial in triggering the relaxation response and has been lauded as an effective treatment for insomnia. As we age, it is crucial to receive consistent, restorative sleep. Chronic lack of rest can have detrimental effects on mood, cognitive abilities and immune system function. A gentle massage performed in regular intervals can reduce the need for prescription sleeping aids.

The power that therapeutic touch has on the emotional state of the client is undeniable. Many seniors experience feelings of isolation and increased levels of anxiety as they undergo lifestyle changes and begin to experience the deaths of close friends and family members. It is often difficult for an elderly person to accept their own physical limitations that make it difficult or even impossible to perform the activities that brought them a lifetime of enjoyment. This causes a rise in anxiety and depression, often adding to a senior’s existing feelings of isolation. A gentle, caring touch can convey feelings of intimacy, empathy and can foster a deep connection between client and caregiver.

A study by the American Public Health Association (APHA) concluded that senior citizens who were given therapeutic massage experienced improvement in vitality, anxiety, depression, positive well-being and general health. These results were found in both independent and community dwelling adults. Moreover, the simple comfort that human contact conveys can be a cherished occasion for seniors who experience depression and loneliness. Geriatric massage is indeed an important tool to enhance the health and well-being of our aging loved ones.

Brandon Thomas is a nationally certified massage therapist and founder of JoyLife Therapeutics. JoyLife Therapeutics provides chair massage, corporate massage, office massage, special event and trade show massage throughout the US.

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